| | | | | | |
| V. Hedman | D | TB | 9/26/2025 | Makes precautionary exit | Undisclosed | + |
| W. Borgen | D | NYR | 10/16/2025 | Game-time decision | lower body | + |
| E. Bear | D | NYI | 9/26/2025 | Exits early | Undisclosed | + |
| D. Forbor | D | VAN | 10/15/2025 | Placed on injured reserve | Undisclosed | + |
| J. Chatfi | D | CAR | 9/21/2025 | Unlikely to play in preseason | Undisclosed | + |
| H. Mews | D | CGY | 11/4/2025 | Done for season | knee | + |
| M. Crozie | D | TB | 10/14/2025 | Exits Tuesday's game | Undisclosed | + |
| J. Slavin | D | CAR | 9/21/2025 | Likely held out of preseason action | Undisclosed | + |
| M. Crozie | D | TB | 10/14/2025 | doubtful | Undisclosed | + |
| D. Kuliko | D | FLA | 10/15/2025 | Will miss approximately five months | Upper body | + |
| E. Gudbra | D | CBJ | 11/4/2025 | Still sidelined | hip | + |
| W. Borgen | D | NYR | 10/15/2025 | Managing lower-body injury | lower body | + |
| A. Romano | D | NYI | 10/18/2025 | Game-time decision | Undisclosed | + |
| O. Bonk | D | PHI | 9/23/2025 | Not in lineup | Upper body | + |
| K. Guhle | D | MTL | 10/18/2025 | Set to miss 4-6 weeks | lower body | + |
| E. Gudbra | D | CBJ | 10/18/2025 | Unavailable | Upper body | + |
| T. Harley | D | DAL | 10/18/2025 | Game-time decision | illness | + |
| C. Tanev | D | TOR | 11/1/2025 | Taken out on stretcher | Upper body | + |
| N. Lundkv | D | DAL | 10/17/2025 | Suffers lower-body injury | lower body | + |
| E. Gudbra | D | CBJ | 10/16/2025 | Remains out | Upper body | + |
| C. Tanev | D | TOR | 11/2/2025 | Discharged and headed home | Upper body | + |
| T. Harley | D | DAL | 10/17/2025 | Dealing with illness | illness | + |
| Z. Parekh | D | CGY | 11/8/2025 | Will miss time | Upper body | + |
| Z. Parekh | D | CGY | 11/7/2025 | Suffers upper-body injury | Upper body | + |
| J. Slavin | D | CAR | 10/13/2025 | Still being evaluated | lower body | + |
| C. Tanev | D | TOR | 11/8/2025 | Returns to ice | Upper body | + |
| S. Durzi | D | UTA | 10/13/2025 | Set to miss four weeks | Upper body | + |
| G. Briseb | D | VAN | 9/27/2025 | Undergoes surgery | lower body | + |
| E. Gudbra | D | CBJ | 10/11/2025 | Leaves with upper-body injury | Upper body | + |
| H. Fleury | D | WIN | 10/12/2025 | Officially day-to-day | Kneecap | + |
| R. McDona | D | TB | 11/8/2025 | Leaves Saturday's game | Undisclosed | + |
| J. Slavin | D | CAR | 10/11/2025 | Sustains injury | Undisclosed | + |
| S. Durzi | D | UTA | 10/11/2025 | Hurt late | Undisclosed | + |
| M. Crozie | D | TB | 11/8/2025 | Still hampered by injury | Undisclosed | + |
| E. Gudbra | D | CBJ | 10/13/2025 | Unavailable | Upper body | + |
| J. Chatfi | D | CAR | 11/8/2025 | Out indefinitely | Upper body | + |
| C. McAvoy | D | BOS | 11/8/2025 | Unavailable | Personal | + |
| Z. Parekh | D | CGY | 11/8/2025 | Out week-to-week | Upper body | + |
| H. Fleury | D | WIN | 10/13/2025 | Won't play | Kneecap | + |
| O. Bonk | D | PHI | 9/27/2025 | Still out of action. | Upper body | + |
| J. Lauzon | D | VGK | 9/19/2025 | Precautionary absence from practice | Undisclosed | + |
| J. Slavin | D | CAR | 10/14/2025 | Not on road trip | lower body | + |
| J. Chatfi | D | CAR | 11/6/2025 | Suffers upper-body injury | Upper body | + |
| V. Hedman | D | TB | 9/27/2025 | Sitting out | Undisclosed | + |
| N. Lundkv | D | DAL | 10/18/2025 | Game-time call | lower body | + |
| R. Ristol | D | PHI | 10/27/2025 | Still 4-6 week from returning | Triceps | + |
| A. Romano | D | NYI | 10/22/2025 | Not close to returning | Upper body | + |
| O. Bonk | D | PHI | 10/27/2025 | Progressing in recovery | Upper body | + |
| M. Kessel | D | BUF | 10/22/2025 | Could resume practicing soon | lower body | + |
| C. Tanev | D | TOR | 10/22/2025 | Questionable for Friday's game | Upper body | + |
| M. Kessel | D | BUF | 10/27/2025 | Likely to return | lower body | + |
| E. Gudbra | D | CBJ | 10/28/2025 | out | hip | + |
| M. Crozie | D | TB | 10/21/2025 | Won't play in next three games | Undisclosed | + |
| E. Gudbra | D | CBJ | 10/21/2025 | Not playing | Upper body | + |
| C. Tanev | D | TOR | 10/21/2025 | Sustains upper-body injury | Upper body | + |
| B. Pesce | D | NJ | 10/28/2025 | Out for at least one month | Upper body | + |
| C. Tanev | D | TOR | 10/27/2025 | Could return by end of week | Upper body | + |
| O. Bonk | D | PHI | 9/25/2025 | Unavailable | Upper body | + |
| R. Josi | D | NSH | 10/25/2025 | Deemed week-to-week | Upper body | + |
| D. Forbor | D | VAN | 10/24/2025 | Considered week-to-week | Undisclosed | + |
| A. Romano | D | NYI | 10/27/2025 | Won't play | Upper body | + |
| B. Pesce | D | NJ | 10/26/2025 | Won't travel with team | Upper body | + |
| N. Lundkv | D | DAL | 10/18/2025 | Sitting out | lower body | + |
| N. Lundkv | D | DAL | 10/18/2025 | Expected to miss some time. | lower body | + |
| J. Lauzon | D | VGK | 9/23/2025 | Sitting out | Undisclosed | + |
| M. Rifai | D | TOR | 9/26/2025 | Needs wrist surgery | wrist | + |
| A. Romano | D | NYI | 10/18/2025 | Not playing | Upper body | + |
| E. Gudbra | D | CBJ | 11/1/2025 | Ruled out of weekend games | hip | + |
| C. Tanev | D | TOR | 10/31/2025 | Likely | concussion | + |
| K. Guhle | D | MTL | 9/25/2025 | Suffers groin injury | groin | + |
| E. Gudbra | D | CBJ | 10/29/2025 | Remains out for Wednesday's game | hip | + |
| M. Rifai | D | TOR | 9/25/2025 | Suffers upper-body injury | Upper body | + |
| A. Romano | D | NYI | 10/21/2025 | Unavailable against San Jose | Upper body | + |
| J. Lauzon | D | VGK | 9/25/2025 | Won't play | Undisclosed | + |
| J. Harris | D | BOS | 10/30/2025 | Undergoes surgery | ankle | + |
| Z. Parekh | D | CGY | 10/30/2025 | Not playing | illness | + |
| J. Lauzon | D | VGK | 9/26/2025 | Remains out against Sharks | Undisclosed | + |
| M. Crozie | D | TB | 10/30/2025 | Practicing in regular jersey | Undisclosed | + |
| M. Crozie | D | TB | 10/30/2025 | Not playing | Undisclosed | + |
| A. Romano | D | NYI | 10/20/2025 | Game-time call | Upper body | + |
| M. Kessel | D | BUF | 11/17/2025 | Set for extended absence | lower body | + |
| W. Borgen | D | NYR | 11/16/2025 | Remains out for Sunday's game | Upper body | + |
| C. McAvoy | D | BOS | 11/17/2025 | No timeline for return | Upper body | + |
| M. Kessel | D | BUF | 10/3/2025 | Ruled out against Pens | Undisclosed | + |
| J. Slavin | D | CAR | 9/30/2025 | Skating in non-contact jersey | Undisclosed | + |
| I. Lyubus | D | DAL | 11/16/2025 | Doesn't skate | Undisclosed | + |
| J. Chatfi | D | CAR | 9/30/2025 | Wearing regular jersey | Undisclosed | + |
| M. Kessel | D | BUF | 10/3/2025 | Considered week-to-week | Undisclosed | + |
| V. Hedman | D | TB | 11/16/2025 | Unavailable | Undisclosed | + |
| V. Hedman | D | TB | 10/2/2025 | Ruled out for Thursday's game | Undisclosed | + |
| J. Lauzon | D | VGK | 11/17/2025 | Dealing with undisclosed injury | Undisclosed | + |
| C. Tanev | D | TOR | 11/18/2025 | Out at least one more week | Upper body | + |
| J. Ivany | D | PIT | 11/18/2025 | Wearing non-contact jersey | lower body | + |
| E. Cernak | D | TB | 10/2/2025 | Misses third period | Undisclosed | + |
| D. Dought | D | LA | 11/17/2025 | Labeled week-to-week | lower body | + |
| B. Pesce | D | NJ | 10/2/2025 | Exits early | Undisclosed | + |
| E. Bear | D | NYI | 10/4/2025 | Likely out for weeks | Undisclosed | + |
| T. Harley | D | DAL | 11/15/2025 | Game-time call | Undisclosed | + |
| V. Hedman | D | TB | 11/15/2025 | Won't return | Undisclosed | + |
| J. Lauzon | D | VGK | 9/29/2025 | Won't suit up | Undisclosed | + |
| V. Hedman | D | TB | 10/4/2025 | Unavailable | Undisclosed | + |
| E. Cernak | D | TB | 10/4/2025 | out | Undisclosed | + |
| T. Harley | D | DAL | 11/15/2025 | Sitting out Saturday, week-to-week | lower body | + |
| W. Borgen | D | NYR | 11/15/2025 | Won't play | Upper body | + |
| D. Dought | D | LA | 11/15/2025 | Sustains lower-body injury | lower body | + |
| M. Kessel | D | BUF | 11/15/2025 | Dealing with lower-body injury | lower body | + |
| C. McAvoy | D | BOS | 11/15/2025 | Suffers upper-body injury | Upper body | + |
| O. Bonk | D | PHI | 9/16/2025 | Dealing with UBI | Upper body | + |
| B. Pesce | D | NJ | 10/3/2025 | Skating | Undisclosed | + |
| R. Ristol | D | PHI | 9/16/2025 | Still working way back from injury | Triceps | + |
| B. Carlo | D | TOR | 11/15/2025 | Not playing | lower body | + |
| V. Hedman | D | TB | 11/20/2025 | Out a couple of weeks | Undisclosed | + |
| V. Hedman | D | TB | 11/20/2025 | Placed on injured reserve | Undisclosed | + |
| S. Durzi | D | UTA | 11/20/2025 | Close to returning | shoulder | + |
| W. Borgen | D | NYR | 11/20/2025 | Considered day-to-day | Upper body | + |
| C. McAvoy | D | BOS | 11/19/2025 | Has facial surgery | Upper body | + |
| J. Lauzon | D | VGK | 10/1/2025 | Won't face Colorado | Undisclosed | + |
| J. Ivany | D | PIT | 11/21/2025 | Sheds non-contact jersey | lower body | + |
| J. Chatfi | D | CAR | 11/21/2025 | Game-time decision | Upper body | + |
| L. Marrel | D | CBJ | 9/8/2025 | Suffers shoulder injury | shoulder | + |
| E. Cernak | D | TB | 11/20/2025 | Remains out | lower body | + |
| J. MacDon | D | COL | 9/4/2025 | Undergoes hip surgery | hip | + |
| N. Matinp | D | OTT | 11/21/2025 | Unable to return | Undisclosed | + |
| O. Bonk | D | PHI | 10/1/2025 | Set to miss two more weeks | Upper body | + |
| I. Lyubus | D | DAL | 11/18/2025 | Won't play | Undisclosed | + |
| J. Ivany | D | PIT | 10/2/2025 | Won't practice | lower body | + |
| J. Lauzon | D | VGK | 11/18/2025 | Remains sidelined | Undisclosed | + |
| J. Ivany | D | PIT | 10/2/2025 | Set for six-week absence | lower body | + |
| C. McAvoy | D | BOS | 11/18/2025 | Won't travel on road trip out west | Upper body | + |
| K. Guhle | D | MTL | 9/30/2025 | Shelved versus Sens | groin | + |
| J. Ivany | D | PIT | 10/1/2025 | Leaves Wednesday's contest | lower body | + |
| T. Harley | D | DAL | 11/19/2025 | Will miss road trip | lower body | + |
| I. Lyubus | D | DAL | 11/19/2025 | Won't travel with team | Undisclosed | + |
| R. Ristol | D | PHI | 9/11/2025 | Resumes skating | Triceps | + |
| E. Cernak | D | TB | 11/18/2025 | Not playing | lower body | + |
| E. Bear | D | NYI | 10/2/2025 | Unavailable against Flyers | Undisclosed | + |
| W. Borgen | D | NYR | 11/18/2025 | Labeled game-time call | Upper body | + |
| V. Hedman | D | TB | 11/18/2025 | Won't play | Undisclosed | + |
| A. Romano | D | NYI | 11/18/2025 | Sustains injury late in game | Upper body | + |
| M. Kessel | D | BUF | 10/1/2025 | Early exit | Undisclosed | + |
| T. Chabot | D | OTT | 11/11/2025 | Exits Tuesday's game | Upper body | + |
| V. Hedman | D | TB | 9/29/2025 | Won't play | Undisclosed | + |
| J. MacDon | D | COL | 10/6/2025 | Lands on injured, non-roster list | hip | + |
| V. Hedman | D | TB | 11/12/2025 | Not playing | Undisclosed | + |
| T. Goldsm | D | UTA | 10/6/2025 | Lands on injured, non-roster list | Undisclosed | + |
| H. Fleury | D | WIN | 11/12/2025 | Suffers undisclosed injury | Undisclosed | + |
| T. Chabot | D | OTT | 11/12/2025 | Unavailable | Upper body | + |
| R. McDona | D | TB | 11/11/2025 | Set to miss time | Undisclosed | + |
| C. Legaul | D | CAR | 11/9/2025 | Cut by skate, won't return to game | hand | + |
| C. Legaul | D | CAR | 11/9/2025 | Admitted to hospital | hand | + |