| | | | | | |
| J. Kovace | D | NJ | 9/18/2025 | Ruled out indefinitely | knee | + |
| H. Fleury | D | WIN | 11/12/2025 | Suffers undisclosed injury | Undisclosed | + |
| V. Hedman | D | TB | 11/11/2025 | Dealing with undisclosed injury | Undisclosed | + |
| R. McDona | D | TB | 11/11/2025 | Set to miss time | Undisclosed | + |
| V. Hedman | D | TB | 11/12/2025 | Not playing | Undisclosed | + |
| H. Fleury | D | WIN | 11/13/2025 | In concussion protocol | concussion | + |
| C. Tanev | D | TOR | 11/8/2025 | Returns to ice | Upper body | + |
| Z. Parekh | D | CGY | 11/8/2025 | Will miss time | Upper body | + |
| Z. Parekh | D | CGY | 11/7/2025 | Suffers upper-body injury | Upper body | + |
| C. Legaul | D | CAR | 11/9/2025 | Admitted to hospital | hand | + |
| C. Legaul | D | CAR | 11/9/2025 | Cut by skate, won't return to game | hand | + |
| Z. Parekh | D | CGY | 11/8/2025 | Out week-to-week | Upper body | + |
| R. McDona | D | TB | 11/8/2025 | Leaves Saturday's game | Undisclosed | + |
| V. Hedman | D | TB | 11/16/2025 | Unavailable | Undisclosed | + |
| M. Kessel | D | BUF | 11/17/2025 | Set for extended absence | lower body | + |
| C. Tanev | D | TOR | 11/18/2025 | Out at least one more week | Upper body | + |
| M. Kessel | D | BUF | 11/15/2025 | Dealing with lower-body injury | lower body | + |
| V. Hedman | D | TB | 11/15/2025 | Won't return | Undisclosed | + |
| E. Gudbra | D | CBJ | 10/29/2025 | Remains out for Wednesday's game | hip | + |
| Z. Parekh | D | CGY | 10/30/2025 | Not playing | illness | + |
| J. Harris | D | BOS | 10/30/2025 | Undergoes surgery | ankle | + |
| A. Romano | D | NYI | 10/27/2025 | Won't play | Upper body | + |
| M. Kessel | D | BUF | 10/27/2025 | Likely to return | lower body | + |
| C. Tanev | D | TOR | 10/27/2025 | Could return by end of week | Upper body | + |
| E. Gudbra | D | CBJ | 10/28/2025 | out | hip | + |
| S. Mukham | D | SJ | 10/28/2025 | Classified as day-to-day | Upper body | + |
| Z. Bogosi | D | MIN | 10/28/2025 | Not close to returning | lower body | + |
| H. Mews | D | CGY | 11/4/2025 | Done for season | knee | + |
| C. Tanev | D | TOR | 11/2/2025 | Discharged and headed home | Upper body | + |
| C. Tanev | D | TOR | 11/1/2025 | Taken out on stretcher | Upper body | + |
| C. Tanev | D | TOR | 10/31/2025 | Likely | concussion | + |
| E. Gudbra | D | CBJ | 11/1/2025 | Ruled out of weekend games | hip | + |
| E. Gudbra | D | CBJ | 11/4/2025 | Still sidelined | hip | + |
| B. Montou | D | SEA | 9/17/2025 | Undergoes minor procedure | ankle | + |
| H. Fleury | D | WIN | 12/3/2025 | Starts skating | concussion | + |
| J. Walman | D | EDM | 12/1/2025 | Still sidelined | Undisclosed | + |
| N. Pionk | D | WIN | 12/1/2025 | Ruled out for Monday's game | lower body | + |
| V. Deshar | D | SJ | 12/2/2025 | Deemed week-to-week | Upper body | + |
| B. Montou | D | SEA | 12/2/2025 | Managing issue, could play | Undisclosed | + |
| M. Kessel | D | BUF | 12/2/2025 | Won't travel on road trip | lower body | + |
| J. Bean | D | CGY | 12/8/2025 | Dealing with injury | Undisclosed | + |
| D. Mermis | D | TOR | 12/8/2025 | Will be evaluated | lower body | + |
| J. Walman | D | EDM | 12/8/2025 | Considered week-to-week | Undisclosed | + |
| V. Hedman | D | TB | 12/9/2025 | Exits contest | Undisclosed | + |
| V. Deshar | D | SJ | 12/9/2025 | Out through Christmas | Upper body | + |
| V. Hedman | D | TB | 12/5/2025 | Deemed probable against Islanders | Undisclosed | + |
| H. Fleury | D | WIN | 12/5/2025 | Cleared for contact | concussion | + |
| J. Walman | D | EDM | 12/4/2025 | Remains out | Undisclosed | + |
| J. Walman | D | EDM | 12/6/2025 | Still unavailable | Undisclosed | + |
| L. Bichse | D | DAL | 12/6/2025 | Goes on long-term injured reserve | lower body | + |
| J. Walman | D | EDM | 11/22/2025 | Deemed day-to-day | Undisclosed | + |
| A. Romano | D | NYI | 11/23/2025 | Likely out for season | shoulder | + |
| N. Pionk | D | WIN | 11/23/2025 | Classified as day-to-day | lower body | + |
| N. Pionk | D | WIN | 11/23/2025 | Suffers injury | lower body | + |
| A. Romano | D | NYI | 11/18/2025 | Sustains injury late in game | Upper body | + |
| V. Hedman | D | TB | 11/18/2025 | Won't play | Undisclosed | + |
| Z. Bogosi | D | MIN | 11/18/2025 | Could return in late November | lower body | + |
| V. Hedman | D | TB | 11/20/2025 | Placed on injured reserve | Undisclosed | + |
| V. Hedman | D | TB | 11/20/2025 | Out a couple of weeks | Undisclosed | + |
| N. Pionk | D | WIN | 11/28/2025 | Remains out | lower body | + |
| J. Walman | D | EDM | 11/28/2025 | Ruled out | Undisclosed | + |
| N. Pionk | D | WIN | 11/29/2025 | Won't play | lower body | + |
| L. Bichse | D | DAL | 11/30/2025 | Deemed questionable to return | Undisclosed | + |
| V. Deshar | D | SJ | 11/29/2025 | Dealing with upper-body injury | Upper body | + |
| A. Fox | D | NYR | 11/29/2025 | Exits Saturday's game | Upper body | + |
| N. Pionk | D | WIN | 11/25/2025 | Traveling with team | lower body | + |
| J. Walman | D | EDM | 11/24/2025 | Won't play | Undisclosed | + |
| N. Pionk | D | WIN | 11/26/2025 | Won't play | lower body | + |
| E. Gudbra | D | CBJ | 11/26/2025 | Remains out | hip | + |
| V. Hedman | D | TB | 10/2/2025 | Ruled out for Thursday's game | Undisclosed | + |
| M. Kessel | D | BUF | 10/1/2025 | Early exit | Undisclosed | + |
| J. Walman | D | EDM | 9/30/2025 | Should be ready for regular season | Undisclosed | + |
| V. Hedman | D | TB | 10/4/2025 | Unavailable | Undisclosed | + |
| M. Kessel | D | BUF | 10/6/2025 | Ruled out for Opening Night | Undisclosed | + |
| J. Walman | D | EDM | 10/5/2025 | Suffers injury setback | Undisclosed | + |
| M. Kessel | D | BUF | 10/3/2025 | Ruled out against Pens | Undisclosed | + |
| M. Kessel | D | BUF | 10/3/2025 | Considered week-to-week | Undisclosed | + |
| J. Klingb | D | SJ | 9/25/2025 | Returns to ice | Upper body | + |
| B. Montou | D | SEA | 9/25/2025 | Considered day-to-day | ankle | + |
| J. Klingb | D | SJ | 9/23/2025 | Considered day-to-day | Upper body | + |
| V. Hedman | D | TB | 9/29/2025 | Won't play | Undisclosed | + |
| B. Montou | D | SEA | 9/28/2025 | On track for Opening Night | ankle | + |
| J. Walman | D | EDM | 9/29/2025 | Could play in preseason finale | Undisclosed | + |
| V. Hedman | D | TB | 9/27/2025 | Sitting out | Undisclosed | + |
| G. Briseb | D | VAN | 9/27/2025 | Undergoes surgery | lower body | + |
| J. Walman | D | EDM | 9/27/2025 | Labeled day-to-day | Undisclosed | + |
| V. Hedman | D | TB | 9/26/2025 | Makes precautionary exit | Undisclosed | + |
| Z. Bogosi | D | MIN | 10/20/2025 | Still sidelined against Rangers | lower body | + |
| J. Klingb | D | SJ | 10/18/2025 | Expected to travel for trip | lower body | + |
| S. Mukham | D | SJ | 10/18/2025 | Questionable for road trip | Upper body | + |
| A. Romano | D | NYI | 10/21/2025 | Unavailable against San Jose | Upper body | + |
| J. Klingb | D | SJ | 10/21/2025 | Remains sidelined | lower body | + |
| A. Romano | D | NYI | 10/20/2025 | Game-time call | Upper body | + |
| Z. Bogosi | D | MIN | 10/18/2025 | Won't play | lower body | + |
| B. Montou | D | SEA | 10/18/2025 | Taking leave of absence | Personal | + |
| E. Gudbra | D | CBJ | 10/18/2025 | Unavailable | Upper body | + |
| Z. Bogosi | D | MIN | 10/17/2025 | Injured in Friday's game | Undisclosed | + |
| S. Mukham | D | SJ | 10/17/2025 | Likely out through weekend | Undisclosed | + |
| A. Romano | D | NYI | 10/18/2025 | Game-time decision | Undisclosed | + |
| H. Lindho | D | BOS | 10/18/2025 | Game-time decision | lower body | + |
| A. Romano | D | NYI | 10/18/2025 | Not playing | Upper body | + |
| D. Forbor | D | VAN | 10/24/2025 | Considered week-to-week | Undisclosed | + |
| H. Lindho | D | BOS | 10/25/2025 | Unavailable | Undisclosed | + |
| J. Klingb | D | SJ | 10/24/2025 | Not playing | lower body | + |
| J. Klingb | D | SJ | 10/26/2025 | Won't play | lower body | + |
| A. Romano | D | NYI | 10/22/2025 | Not close to returning | Upper body | + |
| M. Kessel | D | BUF | 10/22/2025 | Could resume practicing soon | lower body | + |
| C. Tanev | D | TOR | 10/22/2025 | Questionable for Friday's game | Upper body | + |
| C. Tanev | D | TOR | 10/21/2025 | Sustains upper-body injury | Upper body | + |
| E. Gudbra | D | CBJ | 10/21/2025 | Not playing | Upper body | + |
| H. Lindho | D | BOS | 10/21/2025 | Still seemingly battling injury | Undisclosed | + |
| J. Klingb | D | SJ | 10/23/2025 | Out again | lower body | + |
| H. Lindho | D | BOS | 10/23/2025 | Remains out | Undisclosed | + |
| H. Lindho | D | BOS | 10/23/2025 | Deemed game-time decision | Undisclosed | + |
| J. Klingb | D | SJ | 10/17/2025 | Sitting out | lower body | + |
| H. Fleury | D | WIN | 10/11/2025 | Suffers injury | Kneecap | + |
| H. Lindho | D | BOS | 10/11/2025 | Won't play | lower body | + |
| H. Fleury | D | WIN | 10/12/2025 | Officially day-to-day | Kneecap | + |
| H. Fleury | D | WIN | 10/13/2025 | Won't play | Kneecap | + |
| E. Gudbra | D | CBJ | 10/11/2025 | Leaves with upper-body injury | Upper body | + |
| H. Lindho | D | BOS | 10/9/2025 | Injury deemed minor | lower body | + |
| J. Walman | D | EDM | 10/7/2025 | Unlikely to play in season opener | Undisclosed | + |
| J. MacDon | D | COL | 10/6/2025 | Lands on injured, non-roster list | hip | + |
| H. Lindho | D | BOS | 10/9/2025 | Suffers lower-body injury | lower body | + |
| D. Kuliko | D | FLA | 10/9/2025 | Exits with injury | Upper body | + |
| H. Lindho | D | BOS | 10/15/2025 | questionable | lower body | + |
| J. Walman | D | EDM | 10/15/2025 | Unavailable | Undisclosed | + |
| J. Klingb | D | SJ | 10/15/2025 | Dealing with lower-body injury | lower body | + |
| D. Forbor | D | VAN | 10/15/2025 | Placed on injured reserve | Undisclosed | + |
| E. Gudbra | D | CBJ | 10/16/2025 | Remains out | Upper body | + |
| J. Klingb | D | SJ | 10/16/2025 | Will travel with team | lower body | + |
| H. Lindho | D | BOS | 10/16/2025 | Won't play | lower body | + |
| D. Kuliko | D | FLA | 10/15/2025 | Will miss approximately five months | Upper body | + |
| J. Walman | D | EDM | 10/14/2025 | Hoping to play | Undisclosed | + |
| E. Gudbra | D | CBJ | 10/13/2025 | Unavailable | Upper body | + |
| H. Lindho | D | BOS | 10/13/2025 | Won't play | lower body | + |
| L. Bichse | D | DAL | 12/21/2025 | Yet to begin rehab | lower body | + |
| B. Montou | D | SEA | 12/20/2025 | Out again | Undisclosed | + |
| C. Timmin | D | BUF | 12/18/2025 | Suffers broken leg | leg | + |
| Z. Bogosi | D | MIN | 12/19/2025 | out | lower body | + |
| J. Bean | D | CGY | 12/18/2025 | Ruled out indefinitely | Undisclosed | + |
| R. McDona | D | TB | 12/27/2025 | Not playing | Undisclosed | + |
| E. Lilleb | D | TB | 12/13/2025 | Doesn't finish game | Undisclosed | + |
| R. McDona | D | TB | 12/15/2025 | Considered day-to-day | Undisclosed | + |
| E. Lilleb | D | TB | 12/15/2025 | Set for extended absence | Undisclosed | + |
| C. Tanev | D | TOR | 12/15/2025 | Sporting regular sweater | Upper body | + |
| H. Fleury | D | WIN | 12/12/2025 | Medically cleared | concussion | + |
| S. Mukham | D | SJ | 12/13/2025 | Not available | Upper body | + |
| B. Montou | D | SEA | 12/17/2025 | Leaves Tuesday's game | Undisclosed | + |
| R. McDona | D | TB | 12/17/2025 | Could return versus Kings | Undisclosed | + |