Age: 39, 210 lbs, 5'10" Born: 4/8/1986, Santo Domingo, Dominican Republic Sal: N/A  Currently In the minors TRANSACTION REPORT 5 daysOptioned to complex league. The Cubs optioned Santana to the Arizona Complex League.
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| 2025 | CHC | 124 | 415 | 91 | 49 | 91 | 11 | 0 | 11 | 135 | 54 | 7 | 0 | 52 | 1 | 7 | 3 | 0 | 4 | 2 | 0.219 | 0.308 | 0.325 | 0.633 | 135.0 | 1.1 |
| 2024 | CLE | 150 | 521 | 99 | 63 | 124 | 26 | 0 | 23 | 219 | 71 | 4 | 0 | 65 | 3 | 11 | 6 | 0 | 2 | 4 | 0.238 | 0.328 | 0.420 | 0.749 | 219.0 | 1.5 |
| 2023 | MIL | 146 | 550 | 104 | 78 | 132 | 33 | 1 | 23 | 236 | 86 | 6 | 0 | 65 | 0 | 11 | 0 | 0 | 4 | 8 | 0.240 | 0.318 | 0.429 | 0.747 | 236.0 | 1.6 |
| 2022 | PIT | 131 | 431 | 88 | 52 | 87 | 18 | 0 | 19 | 162 | 60 | 0 | 0 | 71 | 2 | 9 | 2 | 0 | 2 | 2 | 0.202 | 0.316 | 0.376 | 0.692 | 162.0 | 1.2 |
| 2021 | KC | 158 | 565 | 102 | 66 | 121 | 15 | 0 | 19 | 193 | 69 | 2 | 0 | 86 | 3 | 12 | 3 | 0 | 5 | 7 | 0.214 | 0.319 | 0.342 | 0.660 | 193.0 | 1.2 |
| 2020 | KC | 61 | 206 | 43 | 34 | 41 | 7 | 0 | 8 | 72 | 30 | 0 | 0 | 47 | 1 | 5 | 1 | 0 | 1 | 4 | 0.199 | 0.349 | 0.350 | 0.699 | 72.0 | 1.2 |
| 2019 | CLE | 158 | 573 | 108 | 110 | 161 | 30 | 1 | 34 | 295 | 93 | 4 | 0 | 108 | 12 | 13 | 3 | 0 | 2 | 10 | 0.281 | 0.397 | 0.515 | 0.911 | 295.0 | 1.9 |
| 2018 | CLE | 161 | 560 | 93 | 82 | 128 | 28 | 2 | 24 | 232 | 86 | 2 | 1 | 110 | 6 | 12 | 1 | 0 | 8 | 11 | 0.229 | 0.352 | 0.414 | 0.766 | 232.0 | 1.4 |
| 2017 | PHI | 154 | 571 | 94 | 90 | 148 | 37 | 3 | 23 | 260 | 79 | 5 | 1 | 88 | 6 | 11 | 6 | 0 | 2 | 5 | 0.259 | 0.363 | 0.455 | 0.818 | 260.0 | 1.7 |
| 2016 | CLE | 158 | 582 | 99 | 89 | 151 | 31 | 3 | 34 | 290 | 87 | 5 | 2 | 99 | 0 | 18 | 2 | 0 | 5 | 5 | 0.259 | 0.366 | 0.498 | 0.865 | 290.0 | 1.8 |
| 2015 | CLE | 154 | 550 | 122 | 72 | 127 | 29 | 2 | 19 | 217 | 85 | 11 | 3 | 108 | 8 | 19 | 3 | 0 | 5 | 3 | 0.231 | 0.357 | 0.395 | 0.752 | 217.0 | 1.4 |
| 2014 | CLE | 152 | 541 | 124 | 68 | 125 | 25 | 0 | 27 | 231 | 85 | 5 | 2 | 113 | 5 | 13 | 3 | 0 | 3 | 11 | 0.231 | 0.365 | 0.427 | 0.792 | 231.0 | 1.5 |
| 2013 | CLE | 154 | 541 | 110 | 75 | 145 | 39 | 1 | 20 | 246 | 74 | 3 | 1 | 93 | 6 | 7 | 4 | 0 | 4 | 5 | 0.268 | 0.377 | 0.455 | 0.832 | 246.0 | 1.6 |
| 2012 | CLE | 143 | 507 | 101 | 72 | 128 | 27 | 2 | 18 | 213 | 76 | 3 | 5 | 91 | 4 | 20 | 3 | 0 | 8 | 9 | 0.252 | 0.365 | 0.420 | 0.785 | 213.0 | 1.5 |
| 2011 | CLE | 155 | 552 | 133 | 84 | 132 | 35 | 2 | 27 | 252 | 79 | 5 | 3 | 97 | 5 | 15 | 2 | 0 | 7 | 11 | 0.239 | 0.351 | 0.457 | 0.808 | 252.0 | 1.6 |
| 2010 | CLE | 46 | 150 | 29 | 23 | 39 | 13 | 0 | 6 | 70 | 22 | 3 | 0 | 37 | 2 | 3 | 1 | 0 | 4 | 3 | 0.260 | 0.401 | 0.467 | 0.868 | 70.0 | 1.5 |
| | | 2205 | 7815 | 1540 | 1107 | 1880 | 404 | 17 | 335 | 3323 | 1136 | 65 | 18 | 1330 | 64 | 186 | 43 | 0 | 66 | 100 | 0.239 | 0.352 | 0.422 | 0.774 | 3323.0 | 1.5 |
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| 5/6/2025 | | L9 - 10 | 5 | 0 | 2 | 3 | 0 | 0 | 0 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.600 | 0.600 | 3.000 | 3.600 | 3.0 |
| 5/6/2025 | | W9 - 1 | 4 | 2 | 2 | 1 | 0 | 0 | 1 | 4 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.250 | 0.400 | 1.750 | 2.150 | 4.0 |
| 5/4/2025 | | W5 - 4 | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0.000 | 0.400 | 0.000 | 0.400 | 0.0 |
| 5/3/2025 | | W5 - 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0.000 | 0.500 | 0.000 | 0.500 | 0.0 |
| 5/2/2025 | | L3 - 5 | 4 | 0 | 1 | 2 | 0 | 0 | 1 | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.500 | 0.500 | 2.750 | 3.250 | 5.0 |
| 4/30/2025 | | L2 - 4 | 3 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.333 | 0.333 | 1.000 | 1.333 | 1.0 |
| 4/29/2025 | | L1 - 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.000 | 0.333 | 0.000 | 0.333 | 0.0 |
| 4/28/2025 | | W11 - 1 | 3 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0.667 | 0.667 | 2.000 | 2.667 | 2.0 |
| 4/27/2025 | | W13 - 3 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0.333 | 0.500 | 1.000 | 1.500 | 1.0 |
| 4/26/2025 | | L4 - 5 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0.000 | 0.500 | 0.000 | 0.500 | 0.0 |
| | | | 30 | 5 | 7 | 10 | 0 | 0 | 2 | 16 | 7 | 1 | 0 | 8 | 0 | 0 | 1 | 0 | 1 | 0 | 0.268 | 0.473 | 1.150 | 1.623 | 16.0 |
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| C. Santan | 1B | CHC | 5/28/2015 | Placed on the paternity list. |
| C. Santan | 1B | CHC | 6/6/2014 | Activated from the 7-day DL. |
| C. Santan | 1B | CHC | 5/27/2014 | Placed on the 7-day DL, retroactive to May 26. |
| C. Santan | 1B | CHC | 6/5/2012 | has been activated from the 7-day DL. |
| C. Santan | 1B | CHC | 5/26/2012 | has been placed on the 7-day DL. |
| C. Santan | 1B | CHC | 4/10/2012 | has agreed to terms on a five-year contract. |
| C. Santan | 1B | CHC | 3/3/2012 | has agreed to terms on a one-year contract. |
| C. Santan | 1B | CHC | 9/23/2010 | Transferred from 15-Day disabled list to 60-Day disabled list. |
Stars of the month
Stars of the week
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| July 02, 2025 | C. Santan | CHC | 1B | NA |
| July 03, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 04, 2025 | C. Santan | CHC | 1B | NA |
| July 05, 2025 | C. Santan | CHC | 1B | NA |
| July 06, 2025 | C. Santan | CHC | 1B | NA |
| July 07, 2025 | C. Santan | CHC | 1B | NA |
| July 08, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 09, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 11, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 12, 2025 | C. Santan | CHC | 1B | NA |
| July 13, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 18, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 19, 2025 | C. Santan | CHC | 1B | NA |
| July 20, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 21, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 22, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 23, 2025 | C. Santan | CHC | 1B | NA |
| July 26, 2025 | C. Santan | CHC | 1B | 2nd star |
| July 27, 2025 | C. Santan | CHC | 1B | NA |
| July 28, 2025 | C. Santan | CHC | 1B | NA |
| July 30, 2025 | C. Santan | CHC | 1B | 2nd star |
| August 01, 2025 | C. Santan | CHC | 1B | 2nd star |
| August 02, 2025 | C. Santan | CHC | 1B | 2nd star |
| August 04, 2025 | C. Santan | CHC | 1B | 2nd star |
| August 06, 2025 | C. Santan | CHC | 1B | 2nd star |
| August 08, 2025 | C. Santan | CHC | 1B | 2nd star |
| August 09, 2025 | C. Santan | CHC | 1B | NA |
| August 12, 2025 | C. Santan | CHC | 1B | NA |
| August 15, 2025 | C. Santan | CHC | 1B | 2nd star |
| August 16, 2025 | C. Santan | CHC | 1B | NA |
| August 19, 2025 | C. Santan | CHC | 1B | NA |
| August 22, 2025 | C. Santan | CHC | 1B | 2nd star |
| August 25, 2025 | C. Santan | CHC | 1B | 2nd star |
| September 01, 2025 | C. Santan | CHC | 1B | 3rd star |
| September 07, 2025 | C. Santan | CHC | 1B | NA |
| September 10, 2025 | C. Santan | CHC | 1B | NA |
| September 19, 2025 | C. Santan | CHC | 1B | NA |
| September 23, 2025 | C. Santan | CHC | 1B | 2nd star |
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