| | | | | | |
| M. Tkachu | LW | FLA | 9/3/2025 | Expected to miss start of campaign | groin | + |
| J. MacDon | D | COL | 9/4/2025 | Undergoes hip surgery | hip | + |
| L. Marrel | D | CBJ | 9/8/2025 | Suffers shoulder injury | shoulder | + |
| R. Ristol | D | PHI | 9/11/2025 | Resumes skating | Triceps | + |
| K. Dach | C | MTL | 9/15/2025 | Targeting Opening Night return | knee | + |
| S. Varlam | G | NYI | 9/15/2025 | Status uncertain for start of camp | knee | + |
| O. Bonk | D | PHI | 9/16/2025 | Dealing with UBI | Upper body | + |
| L. Brosso | G | CHI | 9/16/2025 | Still unavailable | knee | + |
| R. Ristol | D | PHI | 9/16/2025 | Still working way back from injury | Triceps | + |
| T. Nosek | LW | FLA | 9/17/2025 | Set to miss several months | knee | + |
| J. Woo | D | VAN | 9/17/2025 | Recovering from surgery | Upper body | + |
| M. Tkachu | LW | FLA | 9/17/2025 | Might return in December | groin | + |
| N. Acciar | C | PIT | 9/17/2025 | Still not cleared to play | Undisclosed | + |
| L. O'Conn | RW | COL | 9/17/2025 | On track for November return | hip | + |
| C. Wheatc | C | DAL | 9/18/2025 | Managing wrist injury | wrist | + |
| J. Kovace | D | NJ | 9/18/2025 | Ruled out indefinitely | knee | + |
| K. McDona | RW | DAL | 9/18/2025 | Sidelined until at least November | knee | + |
| L. Krys | D | DAL | 9/18/2025 | Dealing with Achilles injury | Achilles | + |
| S. Varlam | G | NYI | 9/18/2025 | Skating, no timeline for return | knee | + |
| N. Sturm | C | MIN | 9/18/2025 | Dealing with back injury | back | + |
| P. Engval | LW | NYI | 9/18/2025 | Out 2-3 weeks | hip | + |
| N. Acciar | C | PIT | 9/18/2025 | Dealing with core muscle injury | abdomen | + |
| O. Bonk | D | PHI | 9/18/2025 | Deemed day-to-day | Upper body | + |
| L. Brosso | G | CHI | 9/18/2025 | Remains out long-term | knee | + |
| J. Slavin | D | CAR | 9/18/2025 | Doesn't skate | Undisclosed | + |
| J. Lauzon | D | VGK | 9/19/2025 | Precautionary absence from practice | Undisclosed | + |
| A. Kerfoo | C | UTA | 9/19/2025 | Week-to-week with lower-body injury | lower body | + |
| N. Roy | C | TOR | 9/20/2025 | Dealing with lower-body injury | lower body | + |
| A. Burako | LW | CHI | 9/21/2025 | Missing from practice | lower body | + |
| J. Slavin | D | CAR | 9/21/2025 | Likely held out of preseason action | Undisclosed | + |
| J. McCann | LW | SEA | 9/21/2025 | Considered day-to-day | lower body | + |
| J. Chatfi | D | CAR | 9/21/2025 | Unlikely to play in preseason | Undisclosed | + |
| J. Lauzon | D | VGK | 9/23/2025 | Sitting out | Undisclosed | + |
| O. Bonk | D | PHI | 9/23/2025 | Not in lineup | Upper body | + |
| N. Dowd | C | WSH | 9/23/2025 | Won't practice | Personal | + |
| N. Sturm | C | MIN | 9/23/2025 | Ruled out | back | + |
| N. Roy | C | TOR | 9/23/2025 | Unavailable against Ottawa | lower body | + |
| K. Kakko | RW | SEA | 9/24/2025 | Leaves with injury | Upper body | + |
| N. Acciar | C | PIT | 9/24/2025 | Skating in non-contact jersey | abdomen | + |
| A. Barkov | C | FLA | 9/25/2025 | Seeing doctors | leg | + |
| J. Lauzon | D | VGK | 9/25/2025 | Won't play | Undisclosed | + |
| K. Guhle | D | MTL | 9/25/2025 | Suffers groin injury | groin | + |
| M. Rifai | D | TOR | 9/25/2025 | Suffers upper-body injury | Upper body | + |
| K. Kakko | RW | SEA | 9/25/2025 | Will be evaluated | Upper body | + |
| O. Bonk | D | PHI | 9/25/2025 | Unavailable | Upper body | + |
| N. Hoglan | LW | VAN | 9/25/2025 | Hurt in Wednesday's game | Undisclosed | + |
| N. Dowd | C | WSH | 9/25/2025 | Not playing | Personal | + |
| A. Barkov | C | FLA | 9/25/2025 | Sustains apparent right leg injury | leg | + |
| J. Gadjov | LW | FLA | 9/25/2025 | On the sidelines | lower body | + |
| N. Sturm | C | MIN | 9/25/2025 | Won't play | back | + |
| N. Roy | C | TOR | 9/25/2025 | Remains out of action | lower body | + |
| J. Kulich | C | BUF | 9/25/2025 | Tweaks a muscle | Undisclosed | + |
| K. Kakko | RW | SEA | 9/26/2025 | out | Upper body | + |
| J. McCann | LW | SEA | 9/26/2025 | Absent from lineup | lower body | + |
| N. Hoglan | LW | VAN | 9/26/2025 | Week-to-week | ankle | + |
| M. McLaug | C | NJ | 9/26/2025 | Out for rest of camp | Undisclosed | + |
| E. Bear | D | NYI | 9/26/2025 | Exits early | Undisclosed | + |
| J. Kotkan | LW | CAR | 9/26/2025 | Leaves late in contest | face | + |
| V. Hedman | D | TB | 9/26/2025 | Makes precautionary exit | Undisclosed | + |
| N. Acciar | C | PIT | 9/26/2025 | Not ready | abdomen | + |
| A. Barkov | C | FLA | 9/26/2025 | Missing 7-9 months | knee | + |
| J. Lauzon | D | VGK | 9/26/2025 | Remains out against Sharks | Undisclosed | + |
| M. Rifai | D | TOR | 9/26/2025 | Needs wrist surgery | wrist | + |
| A. Barkov | C | FLA | 9/26/2025 | Undergoing right knee surgery | knee | + |
| K. Kakko | RW | SEA | 9/27/2025 | Set to miss six weeks | hand | + |
| G. Briseb | D | VAN | 9/27/2025 | Undergoes surgery | lower body | + |
| N. Acciar | C | PIT | 9/27/2025 | Remains out of lineup | abdomen | + |
| J. Kulich | C | BUF | 9/27/2025 | Unavailable | Undisclosed | + |
| V. Hedman | D | TB | 9/27/2025 | Sitting out | Undisclosed | + |
| O. Bonk | D | PHI | 9/27/2025 | Still out of action. | Upper body | + |
| J. McCann | LW | SEA | 9/28/2025 | Resumes skating | lower body | + |
| N. Acciar | C | PIT | 9/28/2025 | Won't suit up | abdomen | + |
| P. Holmbe | LW | TB | 9/29/2025 | Ruled out | Undisclosed | + |
| V. Hedman | D | TB | 9/29/2025 | Won't play | Undisclosed | + |
| N. Hoglan | LW | VAN | 9/29/2025 | Set for extended absence | lower body | + |
| J. Lauzon | D | VGK | 9/29/2025 | Won't suit up | Undisclosed | + |
| O. Bonk | D | PHI | 9/29/2025 | Won't play | Upper body | + |
| T. Demko | G | VAN | 9/30/2025 | Away from team for personal reasons | Personal | + |
| N. Sturm | C | MIN | 9/30/2025 | Practices | back | + |
| N. Philp | C | EDM | 9/30/2025 | Battling illness | illness | + |
| K. Guhle | D | MTL | 9/30/2025 | Shelved versus Sens | groin | + |
| J. Chatfi | D | CAR | 9/30/2025 | Wearing regular jersey | Undisclosed | + |
| J. Slavin | D | CAR | 9/30/2025 | Skating in non-contact jersey | Undisclosed | + |
| P. Holmbe | LW | TB | 9/30/2025 | Skating in non-contact jersey | Undisclosed | + |
| J. Lauzon | D | VGK | 10/1/2025 | Won't face Colorado | Undisclosed | + |
| J. Ivany | D | PIT | 10/1/2025 | Leaves Wednesday's contest | lower body | + |
| M. Kessel | D | BUF | 10/1/2025 | Early exit | Undisclosed | + |
| Z. Benson | LW | BUF | 10/1/2025 | Dealing with minor ailment | Undisclosed | + |
| O. Bonk | D | PHI | 10/1/2025 | Set to miss two more weeks | Upper body | + |
| V. Hedman | D | TB | 10/2/2025 | Ruled out for Thursday's game | Undisclosed | + |
| E. Cernak | D | TB | 10/2/2025 | Misses third period | Undisclosed | + |
| B. Pesce | D | NJ | 10/2/2025 | Exits early | Undisclosed | + |
| J. Ivany | D | PIT | 10/2/2025 | Won't practice | lower body | + |
| M. Pospis | C | CGY | 10/2/2025 | Leaves Wednesday's game | Undisclosed | + |
| E. Bear | D | NYI | 10/2/2025 | Unavailable against Flyers | Undisclosed | + |
| P. Holmbe | LW | TB | 10/2/2025 | Cleared for contact | Undisclosed | + |
| J. Ivany | D | PIT | 10/2/2025 | Set for six-week absence | lower body | + |
| B. Pesce | D | NJ | 10/3/2025 | Skating | Undisclosed | + |
| Z. Benson | LW | BUF | 10/3/2025 | Still out | Undisclosed | + |
| M. Kessel | D | BUF | 10/3/2025 | Ruled out against Pens | Undisclosed | + |
| M. Pospis | C | CGY | 10/3/2025 | Won't play | Undisclosed | + |
| M. Kessel | D | BUF | 10/3/2025 | Considered week-to-week | Undisclosed | + |
| E. Bear | D | NYI | 10/4/2025 | Likely out for weeks | Undisclosed | + |
| E. Cernak | D | TB | 10/4/2025 | out | Undisclosed | + |
| V. Hedman | D | TB | 10/4/2025 | Unavailable | Undisclosed | + |
| C. Wheatc | C | DAL | 10/6/2025 | Placed on non-roster IR | wrist | + |
| K. McDona | RW | DAL | 10/6/2025 | Placed on non-roster IR | knee | + |
| J. MacDon | D | COL | 10/6/2025 | Lands on injured, non-roster list | hip | + |
| T. Goldsm | D | UTA | 10/6/2025 | Lands on injured, non-roster list | Undisclosed | + |
| A. Thornt | G | UTA | 10/6/2025 | Dealing with undisclosed injury | Undisclosed | + |
| M. Pospis | C | CGY | 10/6/2025 | Not available opening night | Undisclosed | + |
| M. Kessel | D | BUF | 10/6/2025 | Ruled out for Opening Night | Undisclosed | + |
| T. Bluege | C | VAN | 10/7/2025 | Set to miss some time | Undisclosed | + |
| N. Sturm | C | MIN | 10/8/2025 | Expected to miss significant time | back | + |
| D. Kuliko | D | FLA | 10/9/2025 | Exits with injury | Upper body | + |
| J. Dickin | C | CHI | 10/9/2025 | Sustains injury | Undisclosed | + |
| Z. Benson | LW | BUF | 10/9/2025 | In hospital for facial cut | face | + |
| J. Norris | C | BUF | 10/9/2025 | Hurt late in Thursday's game | Upper body | + |
| N. Sturm | C | MIN | 10/9/2025 | Slated to miss 6-8 weeks | back | + |
| Z. Benson | LW | BUF | 10/9/2025 | Not in action | Undisclosed | + |
| Z. Benson | LW | BUF | 10/10/2025 | Not playing | face | + |
| J. Norris | C | BUF | 10/10/2025 | Set to miss out | Upper body | + |
| S. Durzi | D | UTA | 10/11/2025 | Hurt late | Undisclosed | + |
| E. Gudbra | D | CBJ | 10/11/2025 | Leaves with upper-body injury | Upper body | + |
| J. Slavin | D | CAR | 10/11/2025 | Sustains injury | Undisclosed | + |
| H. Fleury | D | WIN | 10/11/2025 | Suffers injury | Kneecap | + |
| J. Norris | C | BUF | 10/11/2025 | Out indefinitely | Upper body | + |
| J. Dickin | C | CHI | 10/11/2025 | Likely out for one week | Upper body | + |
| P. Dubois | C | WSH | 10/12/2025 | Exits Sunday's game in Manhattan | Undisclosed | + |
| H. Fleury | D | WIN | 10/12/2025 | Officially day-to-day | Kneecap | + |
| M. Pospis | C | CGY | 10/13/2025 | Not skating yet | Undisclosed | + |
| B. Tkachu | LW | OTT | 10/13/2025 | Injured in Monday's game | wrist | + |
| J. Dickin | C | CHI | 10/13/2025 | Available for Monday's home game | Upper body | + |
| J. Slavin | D | CAR | 10/13/2025 | Still being evaluated | lower body | + |
| Z. Benson | LW | BUF | 10/13/2025 | Not expected to play | face | + |
| J. Norris | C | BUF | 10/13/2025 | Poised for eight-week absence | Upper body | + |
| H. Fleury | D | WIN | 10/13/2025 | Won't play | Kneecap | + |
| E. Gudbra | D | CBJ | 10/13/2025 | Unavailable | Upper body | + |
| Z. MacEwe | C | NJ | 10/13/2025 | Out indefinitely | Undisclosed | + |
| S. Durzi | D | UTA | 10/13/2025 | Set to miss four weeks | Upper body | + |
| J. Dickin | C | CHI | 10/13/2025 | Game-time call against Utah | Upper body | + |
| J. Slavin | D | CAR | 10/14/2025 | Not on road trip | lower body | + |
| T. Bluege | C | VAN | 10/14/2025 | Sporting non-contact jersey | Undisclosed | + |
| A. Hill | G | VGK | 10/14/2025 | Hurt in first period | lower body | + |
| M. Crozie | D | TB | 10/14/2025 | doubtful | Undisclosed | + |
| M. Crozie | D | TB | 10/14/2025 | Exits Tuesday's game | Undisclosed | + |
| P. Dubois | C | WSH | 10/14/2025 | Not playing | lower body | + |
| B. Tkachu | LW | OTT | 10/14/2025 | Set to miss at least four weeks | wrist | + |
| D. Forbor | D | VAN | 10/15/2025 | Placed on injured reserve | Undisclosed | + |
| J. Danfor | RW | BUF | 10/15/2025 | Exits Wednesday's game | lower body | + |