| | | | | | |
| S. Honzek | LW | CGY | 11/16/2025 | Sustains upper-body injury | Upper body | + |
| K. Dach | C | MTL | 11/16/2025 | Will be out for a while. | foot | + |
| V. Hedman | D | TB | 11/16/2025 | Unavailable | Undisclosed | + |
| M. Kessel | D | BUF | 11/17/2025 | Set for extended absence | lower body | + |
| M. Murray | G | SEA | 11/15/2025 | Injured late in first period | lower body | + |
| C. Garlan | RW | VAN | 11/16/2025 | Injured in Tampa Bay | Undisclosed | + |
| S. Honzek | LW | CGY | 11/16/2025 | Status now week-to-week | Upper body | + |
| F. Chytil | C | VAN | 11/16/2025 | Skating again and feeling better | Upper body | + |
| T. Bluege | C | VAN | 11/16/2025 | Skating again | lower body | + |
| T. Demko | G | VAN | 11/16/2025 | Deemed week-to-week | lower body | + |
| J. Beeche | C | CGY | 11/13/2025 | Remains out | Upper body | + |
| H. Fleury | D | WIN | 11/13/2025 | In concussion protocol | concussion | + |
| A. Newhoo | C | MTL | 11/13/2025 | Sustains apparent lower-body injury | lower body | + |
| W. Karlss | C | VGK | 11/13/2025 | Is week-to-week | lower body | + |
| V. Hedman | D | TB | 11/12/2025 | Not playing | Undisclosed | + |
| Z. MacEwe | C | NJ | 11/13/2025 | Exits Wednesday's contest | Undisclosed | + |
| A. Stolar | G | TOR | 11/13/2025 | Labeled day-to-day | Upper body | + |
| M. Rossi | C | VAN | 11/14/2025 | Considered week-to-week | lower body | + |
| J. Beeche | C | CGY | 11/15/2025 | Not playing | Upper body | + |
| V. Hedman | D | TB | 11/15/2025 | Won't return | Undisclosed | + |
| M. Kessel | D | BUF | 11/15/2025 | Dealing with lower-body injury | lower body | + |
| J. Benn | C | DAL | 11/15/2025 | Considered day-to-day | Upper body | + |
| F. Nazar | C | CHI | 11/14/2025 | Status uncertain | abdomen | + |
| A. Newhoo | C | MTL | 11/14/2025 | Undergoes surgery | ankle | + |
| F. Nazar | C | CHI | 11/15/2025 | Game-time decision | abdomen | + |
| E. Dadono | RW | NJ | 11/17/2025 | Traveling with team | hand | + |
| J. Evans | LW | MTL | 11/20/2025 | Exits Thursday's contest | Undisclosed | + |
| S. Honzek | LW | CGY | 11/21/2025 | Undergoes surgery | Upper body | + |
| J. Walman | D | EDM | 11/22/2025 | Deemed day-to-day | Undisclosed | + |
| V. Hedman | D | TB | 11/20/2025 | Placed on injured reserve | Undisclosed | + |
| A. Stolar | G | TOR | 11/20/2025 | Still not skating | Upper body | + |
| V. Hedman | D | TB | 11/20/2025 | Out a couple of weeks | Undisclosed | + |
| A. Romano | D | NYI | 11/23/2025 | Likely out for season | shoulder | + |
| J. Walman | D | EDM | 11/24/2025 | Won't play | Undisclosed | + |
| T. Demko | G | VAN | 11/24/2025 | Will make road trip | lower body | + |
| P. Kochet | G | CAR | 11/25/2025 | Ruled out against Rangers | Undisclosed | + |
| N. Pionk | D | WIN | 11/23/2025 | Suffers injury | lower body | + |
| N. Pionk | D | WIN | 11/23/2025 | Classified as day-to-day | lower body | + |
| B. Rust | RW | PIT | 11/24/2025 | Dealing with illness | illness | + |
| C. Tanev | D | TOR | 11/18/2025 | Out at least one more week | Upper body | + |
| E. Lindho | C | BOS | 11/18/2025 | Joining team on road trip | lower body | + |
| M. Murray | G | SEA | 11/18/2025 | Out for approximately six weeks | lower body | + |
| C. Garlan | RW | VAN | 11/17/2025 | Unavailable | Undisclosed | + |
| L. O'Conn | RW | COL | 11/17/2025 | Dealing with setback in recovery | hip | + |
| C. Schwin | RW | FLA | 11/17/2025 | Injured in Monday's victory | Undisclosed | + |
| E. Dadono | RW | NJ | 11/18/2025 | Game-time decision | hand | + |
| N. Philp | C | CAR | 11/19/2025 | Sustains upper-body injury | Upper body | + |
| C. Schwin | RW | FLA | 11/19/2025 | Out several months with broken arm | arm | + |
| T. Bluege | C | VAN | 11/19/2025 | Suffers setback in recovery | lower body | + |
| Z. Bogosi | D | MIN | 11/18/2025 | Could return in late November | lower body | + |
| V. Hedman | D | TB | 11/18/2025 | Won't play | Undisclosed | + |
| A. Romano | D | NYI | 11/18/2025 | Sustains injury late in game | Upper body | + |
| T. Demko | G | VAN | 11/7/2025 | In doubt for back-to-back | Undisclosed | + |
| F. Nazar | C | CHI | 11/7/2025 | Departs Friday's game | Undisclosed | + |
| Z. Parekh | D | CGY | 11/7/2025 | Suffers upper-body injury | Upper body | + |
| J. Benn | C | DAL | 11/6/2025 | Participates in optional skate | Upper body | + |
| J. Beeche | C | CGY | 11/6/2025 | Exits contest | Upper body | + |
| F. Hallan | C | PIT | 11/7/2025 | Facing long-term absence | leg | + |
| Z. Parekh | D | CGY | 11/8/2025 | Will miss time | Upper body | + |
| T. Demko | G | VAN | 11/8/2025 | Won't dress | Undisclosed | + |
| J. Gadjov | LW | FLA | 11/8/2025 | Undergoes surgery | Upper body | + |
| J. Beeche | C | CGY | 11/8/2025 | Won't play | Upper body | + |
| F. Nazar | C | CHI | 11/8/2025 | Deemed day-to-day | Undisclosed | + |
| C. Tanev | D | TOR | 11/8/2025 | Returns to ice | Upper body | + |
| Z. Parekh | D | CGY | 11/8/2025 | Out week-to-week | Upper body | + |
| F. Hallan | C | PIT | 11/6/2025 | Not playing | Undisclosed | + |
| J. Gadjov | LW | FLA | 11/3/2025 | Not going on road trip | Upper body | + |
| M. Barron | LW | WIN | 11/3/2025 | Considered week-to-week | Undisclosed | + |
| J. Kulich | C | BUF | 11/4/2025 | Unlikely to play | ear | + |
| P. Dubois | C | WSH | 11/3/2025 | Set to miss extended time | lower body | + |
| E. Lindho | C | BOS | 11/3/2025 | Deemed week-to-week | lower body | + |
| J. Kulich | C | BUF | 11/3/2025 | Doubtful for Tuesday's game | Undisclosed | + |
| E. Gudbra | D | CBJ | 11/4/2025 | Still sidelined | hip | + |
| T. Jarry | G | EDM | 11/5/2025 | Set for three-week absence | lower body | + |
| Z. MacEwe | C | NJ | 11/5/2025 | Not available | Upper body | + |
| F. Hallan | C | PIT | 11/6/2025 | Injured at practice | Undisclosed | + |
| P. Dubois | C | WSH | 11/4/2025 | Avoids season-ending injury | lower body | + |
| T. Dellan | C | SJ | 11/4/2025 | Dealing with lower-body issue | lower body | + |
| H. Mews | D | CGY | 11/4/2025 | Done for season | knee | + |
| F. Nazar | C | CHI | 11/11/2025 | Set to miss out | Undisclosed | + |
| M. Barron | LW | WIN | 11/11/2025 | Labeled day-to-day | Undisclosed | + |
| J. Beeche | C | CGY | 11/11/2025 | Still out | Upper body | + |
| V. Hedman | D | TB | 11/11/2025 | Dealing with undisclosed injury | Undisclosed | + |
| R. McDona | D | TB | 11/11/2025 | Set to miss time | Undisclosed | + |
| L. O'Conn | RW | COL | 11/11/2025 | Still working way back from injury | hip | + |
| A. Stolar | G | TOR | 11/11/2025 | Hurt in first period | Upper body | + |
| T. Demko | G | VAN | 11/12/2025 | Being evaluated | lower body | + |
| T. Foerst | RW | PHI | 11/12/2025 | Game-time call | lower body | + |
| J. Kivira | RW | COL | 11/12/2025 | Skating | lower body | + |
| T. Demko | G | VAN | 11/11/2025 | Departs Tuesday's game | Undisclosed | + |
| T. Demko | G | VAN | 11/12/2025 | Dealing with new lower-body issue | lower body | + |
| H. Fleury | D | WIN | 11/12/2025 | Suffers undisclosed injury | Undisclosed | + |
| T. Foerst | RW | PHI | 11/11/2025 | Sporting regular sweater | lower body | + |
| P. Dubois | C | WSH | 11/9/2025 | Needs surgery | abdomen | + |
| F. Nazar | C | CHI | 11/9/2025 | Game-time decision | Undisclosed | + |
| F. Nazar | C | CHI | 11/9/2025 | Won't play | Undisclosed | + |
| R. McDona | D | TB | 11/8/2025 | Leaves Saturday's game | Undisclosed | + |
| W. Karlss | C | VGK | 11/8/2025 | Suffers injury | Undisclosed | + |
| W. Karlss | C | VGK | 11/9/2025 | Dealing with lower-body injury | lower body | + |
| T. Demko | G | VAN | 11/9/2025 | Not available against Colorado | Undisclosed | + |
| J. Kulich | C | BUF | 11/10/2025 | Set to miss significant time | ear | + |
| W. Karlss | C | VGK | 11/10/2025 | Unavailable | lower body | + |
| M. Wood | LW | CBJ | 11/10/2025 | Under the weather | illness | + |
| C. Legaul | D | CAR | 11/9/2025 | Cut by skate, won't return to game | hand | + |
| J. Benn | C | DAL | 11/9/2025 | Joining team on upcoming road trip | Upper body | + |
| C. Legaul | D | CAR | 11/9/2025 | Admitted to hospital | hand | + |
| N. Philp | C | CAR | 12/8/2025 | Returns to practice | Upper body | + |
| J. Walman | D | EDM | 12/8/2025 | Considered week-to-week | Undisclosed | + |
| D. Mermis | D | TOR | 12/8/2025 | Will be evaluated | lower body | + |
| L. Cooley | C | UTA | 12/8/2025 | Out indefinitely | lower body | + |
| J. Bean | D | CGY | 12/8/2025 | Dealing with injury | Undisclosed | + |
| T. Bluege | C | VAN | 12/8/2025 | Hopes to return after Christmas | lower body | + |
| V. Deshar | D | SJ | 12/9/2025 | Out through Christmas | Upper body | + |
| V. Hedman | D | TB | 12/9/2025 | Exits contest | Undisclosed | + |
| N. Bjugst | C | STL | 12/9/2025 | Won't finish contest | Upper body | + |
| F. Vatran | LW | ANA | 12/9/2025 | Doesn't finish game | face | + |
| A. Edstro | C | NYR | 12/9/2025 | Not traveling with the team | lower body | + |
| T. Demko | G | VAN | 12/9/2025 | Tracking toward return | lower body | + |
| A. Kerfoo | C | UTA | 12/9/2025 | Practices | abdomen | + |
| H. Fleury | D | WIN | 12/5/2025 | Cleared for contact | concussion | + |
| V. Hedman | D | TB | 12/5/2025 | Deemed probable against Islanders | Undisclosed | + |
| C. Hart | G | VGK | 12/5/2025 | Not available | lower body | + |
| A. Edstro | C | NYR | 12/4/2025 | Unavailable | lower body | + |
| J. Walman | D | EDM | 12/4/2025 | Remains out | Undisclosed | + |
| O. Wiesbl | RW | NSH | 12/4/2025 | Suffers upper-body injury | Upper body | + |
| A. Edstro | C | NYR | 12/6/2025 | Won't play | lower body | + |
| L. Cooley | C | UTA | 12/6/2025 | Late scratch | lower body | + |
| F. Chytil | C | VAN | 12/6/2025 | Continues skating, no timeline | Upper body | + |
| A. Edstro | C | NYR | 12/7/2025 | Remains out of lineup | lower body | + |
| T. Seguin | C | DAL | 12/6/2025 | Placed on long-term injured reserve. | knee | + |
| L. Bichse | D | DAL | 12/6/2025 | Goes on long-term injured reserve | lower body | + |
| J. Walman | D | EDM | 12/6/2025 | Still unavailable | Undisclosed | + |
| J. Evans | LW | MTL | 12/10/2025 | Won't play | Personal | + |
| P. Kurash | LW | SJ | 12/13/2025 | Suffers injury | Upper body | + |
| W. Smith | C | SJ | 12/13/2025 | Sustains injury | Undisclosed | + |
| D. Joshua | LW | TOR | 12/13/2025 | Unavailable | illness | + |
| J. Kivira | RW | COL | 12/12/2025 | questionable | eye | + |
| D. Joshua | LW | TOR | 12/13/2025 | Not at practice | illness | + |
| S. Mukham | D | SJ | 12/13/2025 | Not available | Upper body | + |
| E. Lilleb | D | TB | 12/13/2025 | Doesn't finish game | Undisclosed | + |
| E. Lilleb | D | TB | 12/15/2025 | Set for extended absence | Undisclosed | + |
| D. Hollow | C | STL | 12/15/2025 | Set to miss approximately six weeks | lower body | + |
| C. Tanev | D | TOR | 12/15/2025 | Sporting regular sweater | Upper body | + |
| D. Hollow | C | STL | 12/14/2025 | Hurt during practice | lower body | + |
| M. Marchm | LW | CBJ | 12/14/2025 | Ruled out for Sunday's game | illness | + |
| R. McDona | D | TB | 12/15/2025 | Considered day-to-day | Undisclosed | + |
| B. Horvat | C | NYI | 12/11/2025 | Exits Thursday's game | lower body | + |
| J. Kivira | RW | COL | 12/12/2025 | Sustains upper-body injury | Upper body | + |
| B. Horvat | C | NYI | 12/12/2025 | Set to miss out | lower body | + |
| N. Bjugst | C | STL | 12/10/2025 | Set for five-day absence | Upper body | + |