| | | | | | |
| C. Tanev | D | TOR | 10/27/2025 | Could return by end of week | Upper body | + |
| J. Lauzon | D | VGK | 9/25/2025 | Won't play | Undisclosed | + |
| M. Kessel | D | BUF | 10/27/2025 | Likely to return | lower body | + |
| J. Gadjov | LW | FLA | 10/27/2025 | Out at least one week | Upper body | + |
| M. Rifai | D | TOR | 9/25/2025 | Suffers upper-body injury | Upper body | + |
| A. Romano | D | NYI | 10/27/2025 | Won't play | Upper body | + |
| R. Rakell | C | PIT | 10/26/2025 | Undergoes hand surgery | hand | + |
| C. Glass | C | NJ | 10/26/2025 | Not on upcoming trip | Upper body | + |
| A. Barkov | C | FLA | 9/26/2025 | Undergoing right knee surgery | knee | + |
| M. Duchen | C | DAL | 10/26/2025 | Still unavailable | Upper body | + |
| K. Guhle | D | MTL | 9/25/2025 | Suffers groin injury | groin | + |
| J. Lauzon | D | VGK | 9/26/2025 | Remains out against Sharks | Undisclosed | + |
| B. Pesce | D | NJ | 10/26/2025 | Won't travel with team | Upper body | + |
| K. Kakko | RW | SEA | 9/25/2025 | Will be evaluated | Upper body | + |
| J. Kulich | C | BUF | 9/25/2025 | Tweaks a muscle | Undisclosed | + |
| N. Roy | C | TOR | 9/25/2025 | Remains out of action | lower body | + |
| M. Rempe | C | NYR | 10/28/2025 | Facing long-term absence | Upper body | + |
| E. Gudbra | D | CBJ | 10/28/2025 | out | hip | + |
| N. Dowd | C | WSH | 9/25/2025 | Not playing | Personal | + |
| N. Hoglan | LW | VAN | 9/25/2025 | Hurt in Wednesday's game | Undisclosed | + |
| E. Gudbra | D | CBJ | 10/29/2025 | Remains out for Wednesday's game | hip | + |
| O. Bonk | D | PHI | 9/25/2025 | Unavailable | Upper body | + |
| M. Duchen | C | DAL | 10/28/2025 | Deemed day-to-day | Upper body | + |
| A. Barkov | C | FLA | 9/25/2025 | Seeing doctors | leg | + |
| R. Ristol | D | PHI | 10/27/2025 | Still 4-6 week from returning | Triceps | + |
| O. Bonk | D | PHI | 10/27/2025 | Progressing in recovery | Upper body | + |
| J. Gadjov | LW | FLA | 9/25/2025 | On the sidelines | lower body | + |
| A. Barkov | C | FLA | 9/25/2025 | Sustains apparent right leg injury | leg | + |
| M. Granlu | C | ANA | 10/28/2025 | Set to miss at least 2-3 weeks | lower body | + |
| B. Pesce | D | NJ | 10/28/2025 | Out for at least one month | Upper body | + |
| O. Bonk | D | PHI | 9/27/2025 | Still out of action. | Upper body | + |
| C. Glass | C | NJ | 10/24/2025 | Missing some time | Upper body | + |
| M. Rempe | C | NYR | 10/23/2025 | Suffers upper-body injury | Upper body | + |
| V. Hedman | D | TB | 9/27/2025 | Sitting out | Undisclosed | + |
| J. Kotkan | LW | CAR | 9/26/2025 | Leaves late in contest | face | + |
| D. Forbor | D | VAN | 10/24/2025 | Considered week-to-week | Undisclosed | + |
| J. Kulich | C | BUF | 9/27/2025 | Unavailable | Undisclosed | + |
| P. Dubois | C | WSH | 10/24/2025 | Not available | lower body | + |
| N. Acciar | C | PIT | 9/27/2025 | Remains out of lineup | abdomen | + |
| M. Duchen | C | DAL | 10/23/2025 | Will remain sidelined | Upper body | + |
| G. Briseb | D | VAN | 9/27/2025 | Undergoes surgery | lower body | + |
| N. Acciar | C | PIT | 9/28/2025 | Won't suit up | abdomen | + |
| J. McCann | LW | SEA | 9/28/2025 | Resumes skating | lower body | + |
| T. Bluege | C | VAN | 10/23/2025 | Missing another game | Undisclosed | + |
| J. McCann | LW | SEA | 10/23/2025 | Still out | lower body | + |
| A. Burako | LW | CHI | 10/23/2025 | Not playing | Personal | + |
| K. Kakko | RW | SEA | 9/27/2025 | Set to miss six weeks | hand | + |
| K. Kakko | RW | SEA | 9/26/2025 | out | Upper body | + |
| J. McCann | LW | SEA | 9/26/2025 | Absent from lineup | lower body | + |
| K. Kakko | RW | SEA | 10/25/2025 | Considered day-to-day | hand | + |
| M. Rempe | C | NYR | 10/25/2025 | Not traveling with team | Upper body | + |
| M. Rifai | D | TOR | 9/26/2025 | Needs wrist surgery | wrist | + |
| R. Rakell | C | PIT | 10/25/2025 | Sustains injury late | Undisclosed | + |
| M. Granlu | C | ANA | 10/25/2025 | Suffers lower-body injury | lower body | + |
| N. Hoglan | LW | VAN | 9/26/2025 | Week-to-week | ankle | + |
| N. Acciar | C | PIT | 9/26/2025 | Not ready | abdomen | + |
| V. Hedman | D | TB | 9/26/2025 | Makes precautionary exit | Undisclosed | + |
| M. McLaug | C | NJ | 9/26/2025 | Out for rest of camp | Undisclosed | + |
| M. Duchen | C | DAL | 10/24/2025 | out | Upper body | + |
| A. Kerfoo | C | UTA | 10/24/2025 | Undergoes core muscle surgery | abdomen | + |
| P. Laine | RW | MTL | 10/25/2025 | Out 3-4 months | abdomen | + |
| R. Josi | D | NSH | 10/25/2025 | Deemed week-to-week | Upper body | + |
| E. Bear | D | NYI | 9/26/2025 | Exits early | Undisclosed | + |
| A. Barkov | C | FLA | 9/26/2025 | Missing 7-9 months | knee | + |
| K. Kakko | RW | SEA | 9/24/2025 | Leaves with injury | Upper body | + |
| H. Mews | D | CGY | 11/4/2025 | Done for season | knee | + |
| T. Jarry | G | PIT | 11/5/2025 | Set for three-week absence | lower body | + |
| P. Dubois | C | WSH | 11/4/2025 | Avoids season-ending injury | lower body | + |
| G. Brindl | C | COL | 11/4/2025 | Considered day-to-day | concussion | + |
| A. Burako | LW | CHI | 9/21/2025 | Missing from practice | lower body | + |
| J. McCann | LW | SEA | 9/21/2025 | Considered day-to-day | lower body | + |
| J. Brazea | LW | PIT | 11/5/2025 | Out at least four weeks | Upper body | + |
| N. Acciar | C | PIT | 11/5/2025 | Set to miss at least three weeks | Upper body | + |
| N. Dowd | C | WSH | 9/23/2025 | Won't practice | Personal | + |
| J. Dickin | C | CHI | 11/3/2025 | Lands on IR | shoulder | + |
| J. Gadjov | LW | FLA | 11/3/2025 | Not going on road trip | Upper body | + |
| M. Duchen | C | DAL | 11/3/2025 | Won't play | Upper body | + |
| J. Kulich | C | BUF | 11/4/2025 | Unlikely to play | ear | + |
| E. Gudbra | D | CBJ | 11/4/2025 | Still sidelined | hip | + |
| G. Brindl | C | COL | 11/3/2025 | Recovering from concussion | concussion | + |
| N. Acciar | C | PIT | 11/3/2025 | Injured in Toronto | Upper body | + |
| Z. MacEwe | C | NJ | 11/5/2025 | Not available | Upper body | + |
| F. Hallan | C | PIT | 11/7/2025 | Facing long-term absence | leg | + |
| A. Kerfoo | C | UTA | 9/19/2025 | Week-to-week with lower-body injury | lower body | + |
| N. Roy | C | TOR | 9/20/2025 | Dealing with lower-body injury | lower body | + |
| J. Lauzon | D | VGK | 9/19/2025 | Precautionary absence from practice | Undisclosed | + |
| T. Demko | G | VAN | 11/7/2025 | In doubt for back-to-back | Undisclosed | + |
| M. Duchen | C | DAL | 11/7/2025 | Unavailable | Upper body | + |
| S. Varlam | G | NYI | 9/18/2025 | Skating, no timeline for return | knee | + |
| M. Misa | C | SJ | 11/7/2025 | Is week-to-week | lower body | + |
| J. Slavin | D | CAR | 9/21/2025 | Likely held out of preseason action | Undisclosed | + |
| M. Misa | C | SJ | 11/5/2025 | Will not play | lower body | + |
| C. Glass | C | NJ | 11/5/2025 | Not expected to return | Upper body | + |
| M. Misa | C | SJ | 11/5/2025 | Game-time call | Undisclosed | + |
| M. Duchen | C | DAL | 11/6/2025 | Not playing | Upper body | + |
| M. Misa | C | SJ | 11/6/2025 | Ruled out versus Jets | lower body | + |
| F. Hallan | C | PIT | 11/6/2025 | Injured at practice | Undisclosed | + |
| F. Hallan | C | PIT | 11/6/2025 | Not playing | Undisclosed | + |
| E. Lindho | C | BOS | 10/31/2025 | Set to miss several weeks | lower body | + |
| K. Kakko | RW | SEA | 10/31/2025 | Could return | hand | + |
| J. Dickin | C | CHI | 10/30/2025 | Sustains injury | Undisclosed | + |
| J. Dickin | C | CHI | 10/30/2025 | Aggravates previous injury | shoulder | + |
| P. Dubois | C | WSH | 10/31/2025 | Sustains lower-body injury | lower body | + |
| E. Gudbra | D | CBJ | 11/1/2025 | Ruled out of weekend games | hip | + |
| C. Tanev | D | TOR | 10/31/2025 | Likely | concussion | + |
| G. Brindl | C | COL | 10/31/2025 | Injured | Upper body | + |
| M. Duchen | C | DAL | 10/30/2025 | Won't play | Upper body | + |
| Z. Parekh | D | CGY | 10/30/2025 | Not playing | illness | + |
| M. Crozie | D | TB | 10/30/2025 | Practicing in regular jersey | Undisclosed | + |
| M. Crozie | D | TB | 10/30/2025 | Not playing | Undisclosed | + |
| N. Acciar | C | PIT | 9/24/2025 | Skating in non-contact jersey | abdomen | + |
| E. Lindho | C | BOS | 10/30/2025 | Sustains lower-body injury | lower body | + |
| L. O'Conn | RW | COL | 10/30/2025 | Nearing return | hip | + |
| J. Harris | D | BOS | 10/30/2025 | Undergoes surgery | ankle | + |
| J. Lauzon | D | VGK | 9/23/2025 | Sitting out | Undisclosed | + |
| N. Roy | C | TOR | 9/23/2025 | Unavailable against Ottawa | lower body | + |
| O. Bonk | D | PHI | 9/23/2025 | Not in lineup | Upper body | + |
| C. Smith | LW | NSH | 11/2/2025 | Will be out for a while. | Upper body | + |
| C. Tanev | D | TOR | 11/2/2025 | Discharged and headed home | Upper body | + |
| J. Kulich | C | BUF | 11/3/2025 | Doubtful for Tuesday's game | Undisclosed | + |
| J. Brazea | LW | PIT | 11/3/2025 | Won't play | Upper body | + |
| P. Dubois | C | WSH | 11/3/2025 | Set to miss extended time | lower body | + |
| E. Lindho | C | BOS | 11/3/2025 | Deemed week-to-week | lower body | + |
| J. Brazea | LW | PIT | 11/1/2025 | Unavailable | Upper body | + |
| G. Brindl | C | COL | 11/1/2025 | Not playing | Upper body | + |
| Z. Benson | LW | BUF | 11/1/2025 | Suffered lower-body injury | lower body | + |
| M. Duchen | C | DAL | 11/1/2025 | Not available | Upper body | + |
| J. Dickin | C | CHI | 11/1/2025 | Won't play | shoulder | + |
| C. Tanev | D | TOR | 11/1/2025 | Taken out on stretcher | Upper body | + |
| P. Dubois | C | WSH | 11/1/2025 | Deemed day-to-day | lower body | + |
| C. Smith | LW | NSH | 11/1/2025 | Exits Saturday's game | Upper body | + |
| C. Glass | C | NJ | 10/22/2025 | Unavailable | Upper body | + |
| J. Slavin | D | CAR | 10/13/2025 | Still being evaluated | lower body | + |
| Z. Benson | LW | BUF | 10/13/2025 | Not expected to play | face | + |
| E. Gudbra | D | CBJ | 10/13/2025 | Unavailable | Upper body | + |
| J. Norris | C | BUF | 10/13/2025 | Poised for eight-week absence | Upper body | + |
| S. Durzi | D | UTA | 10/13/2025 | Set to miss four weeks | Upper body | + |
| M. Pospis | C | CGY | 10/13/2025 | Not skating yet | Undisclosed | + |
| J. Dickin | C | CHI | 10/13/2025 | Game-time call against Utah | Upper body | + |
| Z. MacEwe | C | NJ | 10/13/2025 | Out indefinitely | Undisclosed | + |
| S. Durzi | D | UTA | 10/11/2025 | Hurt late | Undisclosed | + |
| E. Gudbra | D | CBJ | 10/11/2025 | Leaves with upper-body injury | Upper body | + |
| M. Kessel | D | BUF | 10/1/2025 | Early exit | Undisclosed | + |
| J. Slavin | D | CAR | 10/11/2025 | Sustains injury | Undisclosed | + |
| P. Dubois | C | WSH | 10/12/2025 | Exits Sunday's game in Manhattan | Undisclosed | + |
| H. Fleury | D | WIN | 10/13/2025 | Won't play | Kneecap | + |
| H. Fleury | D | WIN | 10/12/2025 | Officially day-to-day | Kneecap | + |
| J. Ivany | D | PIT | 10/1/2025 | Leaves Wednesday's contest | lower body | + |
| B. Tkachu | LW | OTT | 10/13/2025 | Injured in Monday's game | wrist | + |
| M. Duchen | C | DAL | 10/15/2025 | Injured | Upper body | + |